A Method for Determining Asymptotes of Home-Range Area Curves

Home-range area curves are used to estimate the number of locations needed to accurately estimate home range size based on the asymptote of the curve. However, the current methodology used to identify asymptotes for home-range area curves is largely subjective and varies between studies. Our objective was to evaluate the use of exponential, Gompertz, logistic, and reciprocal function models as a means for identifying asymptotes of home-range area curves. We radio monitored northern bobwhite (Colinus virginianus) coveys during mid-September through November 2001-2002 in Jim Hogg County, Texas. We calculated home-range size of radiomarked coveys using the 95% fixed kernel with least squares cross validation and minimum convex polygon estimators. We fitted area observations and coefficient of variation to the number of locations using exponential, Gompertz, logistic, and reciprocal function models to estimate the minimum number of locations necessary to obtain a representative home range size for each home range estimator. The various function models consistently provided a relatively good fit for home range area curves and coefficient of variation curves (0.58 ≤ R2 0.99; P \u3c 0.05) for both home range estimators. We used an information-theoretic framework (AICC) to select the best model to estimate area-curve asymptotes. The use of function models appears to provide a structured and useful approach for calculating area-curve asymptotes. We propose that researchers consider the use of such models when determining asymptotes for home-range area curves and that more research be conducted to validate the strength of this method

(Un)twisted: talking back to media representations of eating disorders

In 2014-15, there were several news reports about a rise in the diagnoses and treatment of eating disorders (EDs), as attributed to the use of image-driven social media. Such coverage can be situated within a long history of concern in which those diagnosed with an ED are constructed as ‘especially vulnerable’ to the power of media images – a subjectivity which is pathologised and devalued precisely through its association with femininity. The most incisive objections to EDs being presented as a response to the ‘weight’ of media representation have come from Abigail Bray (2005) in her work on how anorexia is constructed as a reading as well as an eating disorder. Indeed, there is a whole history of empirical work in Feminist Media Studies and Girlhood Studies which has challenged the pernicious construction of female subjectivity as ‘excessively’ invested in, and ‘damaged’ by, the consumption of mass mediated forms. Yet the media consumption practices of those with experience of an ED have not been subject to similar feminist re-evaluation – an omission which this research seeks to address. In exploring the results of 17 semi-structured interviews with people who have experience of an ED discussing their encounters with media representations of EDs (material that is often co-opted into debates about the ‘toxic’ nature of media culture in this regard), this article seeks to intervene in how such imagined media consumption practices are often defined. In seeking to speak back to historically pathologising constructions, the article seeks to explore the qualitative responses in the context of more ‘every day’ understandings of media engagement, thus working against the gendered othering which has persistently occurred

A Search for Dark Higgs Bosons

Recent astrophysical and terrestrial experiments have motivated the proposal of a dark sector with GeV-scale gauge boson force carriers and new Higgs bosons. We present a search for a dark Higgs boson using 516 fb-1 of data collected with the BABAR detector. We do not observe a significant signal and we set 90% confidence level upper limits on the product of the Standard Model-dark sector mixing angle and the dark sector coupling constant.Comment: 7 pages, 5 postscript figures, published version with improved plots for b/w printin

B0 meson decays to rho0 K*0, f0 K*0, and rho-K*+, including higher K* resonances

We present branching fraction measurements for the decays B0 -> rho0 K*0, B0 -> f0 K*0, and B0 -> rho- K*+, where K* is an S-wave (K pi)_0* or a K*(892) meson; we also measure B0 -> f0 K_2*(1430)^0. For the K*(892) channels, we report measurements of longitudinal polarization fractions (for rho final states) and direct CP-violation asymmetries. These results are obtained from a sample of (471.0 +/- 2.8) x 10^6 BBbar pairs collected with the BaBar detector at the PEP-II asymmetric-energy e+ e- collider at the SLAC National Accelerator Laboratory. We observe rho0 K*(892)^0, rho0 (K pi)_0^{*0}, f0 K*(892)^0, and rho- K*(892)+ with greater than 5 sigma significance, including systematics. We report first evidence for f0 (K pi)_0^{*0} and f0 K_2*(1430)^0, and place an upper limit on rho- (K pi)_0^{*+}. Our results in the K*(892) channels are consistent with no direct CP-violation.Comment: 17 pages, 6 postscript figures, submitted to Phys. Rev.

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

A Review of Crippling Loss for Northern Bobwhites

Many studies have reported estimates of crippling loss (i.e., birds shot, noticeably or not, and not retrieved) for northern bobwhites (Colinus virginianus); however, comparisons among studies have been difficult because of a lack of standardized definitions and methods of calculation. The purpose of this paper was to: 1) provide a review of crippling loss of bobwhites across their geographic range, and 2) develop terminology that allowed for explicit discussion of crippling loss and facilitated comparison among studies. We also obtained an estimate of crippling loss for bobwhites in southern Texas using data from a larger study investigating the effects of ranch-road baiting on bobwhites. Reported estimates of crippling loss ranged from 5 to 31% of recorded harvest and 5-24% of total kill. We propose that studies reporting crippling loss use explicit definitions including those developed herein, allowing for inter-study comparisons. Documenting crippling loss in the field should include monitoring of radio-marked bobwhites the morning after a hunt to correctly identify crippled loss birds. In addition, practices (e.g., amount of time spent looking for downed birds) potentially minimizing crippling loss on harvested bobwhite populations should be identified

Geophysics Field Camp 2009

An interdisciplinary survey consisting of four geophysical methods was conducted on the western edge of the Apache Generating Station’s property in Willcox, Arizona. The aim of the survey was to apply various methods for the detection of earth fissures and desiccation cracks. The geophysical methods used were static magnetic field measurements, frequency domain electromagnetics (FEM), ground penetrating radar (GPR), and seismic. Two grids were delineated and surveyed by each method. Grid 1 was set up at a site containing a fissure with visible surface expression over some parts of the grid, and Grid 2 was set up at a site with little visible surface expression of the fissure, but was suspected to contain a fissure in the subsurface. At another location, northwest of the Apache Generating Station, three lines were surveyed in an area of known desiccation cracks. All of the methods showed an anomaly associated with the fissure in Grid 1. Furthermore, at locations where the fissure is not visible in Grid 1, there were still strong anomalies in line with the suspected location of the fissure extending below the surface. Magnetic data from Grid 2 suggests that magnetics may not be a useful method in subsurface earth fissure detection at this site, where we believe that the fissure is only a very small crack with small aperture at depth. The electromagnetic results from Grid 2 show anomalies extending from lines 1 through 5 where there is only minimal surface expression in lines 1 and 2 and no surface expression in lines 3-5. No anomaly was seen in the northern end of Grid 2. It was found that GPR in Grid 2 did not display conclusive results in distinguishing subsurface earth fissure anomalies from other anomalies, such as roots. Seismic lines in Grid 2 show anomalies in the profiles that could indicate the presence of earth fissures; however a thin high velocity horizon may appear as a subsurface fissure, and this made interpretations more challenging. At the desiccation crack site, there is evidence of a shallow feature, which we interpret to be a dessication crack and not an earth fissure. A dirt road was present at the desiccation crack site, and it is possible that the road may have produced some of the observed anomalies due to rain-water channeling effects. The locations of fissures were confirmed by trenches excavated at the locations where anomalies were visible in the geophysical data, but where the fissures were not exposed at the surface.The Geophysics Field Camp Reports are made available by the Laboratory for Advanced Subsurface Imaging (LASI) and the University of Arizona Libraries. Visit the LASI website for more information http://www.lasi.arizona.edu